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Information To buy viagra
Viagra is an oral medicine used for treating male impotence (e.g., erectile dysfunction). Viagra’s advantages are a great safety track record and proven side effects. The effect of Viagra starts in 30 minutes to 1 hour and lasts for about 4 hours.
Drug Name
Buy Viagra (Sildenafil)
Drug Uses
Viagra is used for treating erectile dysfunction (e.g. male impotence). It works by helping the blood flow into the penis to achieve and maintain an erection during sexual stimulation.
How to use
Viagra is to be taken 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Viagra is not supposed to be taken more often than once per day.
Sildenafil (Brand name: Viagra. Kamagra) - Sildenafil is an oral treatment for erectile dysfunction, whether organic or psychogenic in origin. Medical causes of erectile dysfunction include diabetes, and circulatory, neurological or urological conditions.
by admin on October 18, 2011
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Viagra®, Cialis® and Levitra® are oral drugs used successfully for treatment of erectile dysfunction (ED). They work by enhancing the effects of nitric oxide, a mediator that relaxes smooth muscles in the penis, which leads to dilatation of the blood vessels, thus helping the patient achieve and maintain an erection. These medications cause erections only during sexual excitement. They can be taken as often as once a day.
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Viagra History: Discovery Timeline
1989
- Pfizer Scientists synthesize silendafil citrate and give it the code name UK-92, 480. The drug would not be known as Viagra until the mid-90s.
- Experimental compound UK-92,480 is believed to be useful as a high blood pressure and angina treatment. The scientists hope it may act as a vasodilator and be useful in treating cardiovascular ailments such as hypertension and angina.
1991
- Researchers at Pfizer’s Sandwich, England research facility (Peter Ellis and Nick Terret) observe that drugs that inhibit the PDE5 enzyme may be helpful in reversing erectile dysfunction.
- Early Phase 1 trials regarding the use of Viagra for angina are unremarkable.
1992
- A second Phase 1 angina trial reveals that the drug has an unusual side effect; penile erections.
- Phase 2 clinical study is conducted testing silendafil citrate’s usefulness as an angina treatment.
1993
- Pilot study using silendafil citrate as a treatment for erectile dysfunction is conducted in Bristol, England. Test subjects take it three times a day for a week. The studies had only 28 men involved.
1994
- Second pilot study on silendafil as an Erectile dysfunction treatment demonstrates that a once per day dose is able to produce an erection.
- Pfizer realizes it has something important; it accelerates the program examining silendafil citrate for erectile dysfunction.
1994 – 1997
- 21 clinical trials are conducted involving 4,500 men demonstrate that Viagra (as it is now known) is safe and effective.
1997
- Pfizer files a New Drug Application for Viagra (NDA 020895) with the United States FDA. FDA agrees to give it a priority review.
1998
- FDA approves Viagra as the first oral treatment for erectile dysfunction. It was approved with a starting dose of 50 mg with the option to increase the dose to 100mg or reduce it to 25 mg.
Misc:
- FDA lists two patents for Viagra. Patent number 5250534 expires on March 27, 2012. Patent number 6469012 (patent use code U-155; TREATMENT OF ERECTILE DYSFUNCTION) is set to expire on Oct 22, 2019.
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